I've had an OA K45 16 in. bbl. upper for more than ten years, but I only have the plastic body mags so some comments might not apply to the older IMI steel mags that have the magwell adapter welded on. As I hardly ever shoot .45 ACP with any firearm (due to expense), the K45 upper doesn't get shot much. Random thoughts that come to mind:
Some pluses about the K45 - it has a unique blowback system that is milder than "straight" blowback, but less mild than delayed blowback (using a 1928 Thompson delayed blowback for comparison). The mags include a last round bolt hold open trip, so that piece of hardware is not needed elsewhere. As an AR pattern upper, the there are numerous accessories for the upper and whatever AR lower one uses. In particular, the recoil system can readily be "tuned" for very tractable .45 ACP shooting.
Minuses include after winding down for a couple of years, what appears to have been the final demise of OA in early 2020. While Rainier Arms appears to still have K45 mags, the other sites I looked at show the mags as discontinued or out of stock. Other special parts might be difficult, expensive, or impossible to find. Ejectors come to mind. As is the case with other AR pattern uppers, full auto operation requires a bolt carrier that has a sear trip abutment (i.e., a "full auto carrier"). Such a full auto carrier was a special order, $85 item and OA required a copy of ones Form 4 before they would sell the item. That said, it appears that by tig welding and grinding to shape a couple weld runs, one could convert an semi carrier to a full auto carrier. The mags seem to be on the "fat" side and are a bit tight in some lowers that might not have been milled out as much as mil spec requires. I have not done so, but I've read that the long discontinued VM-Hytech magwell adapter with the ejector removed for bolt clearance can be used to hold Uzi .45 ACP mags such as those from IMI (expensive) or relatively low cost (ProMag); however, I don't believe that such an arrangement would provide LRBHO.
Neutral: Full auto rate of fire (rounds per minute) .45 ACP comparisons from own testing using American Eagle 230 gr. round nose ammo: Uzi: 680s; 1928 Thompson: mid 800s; OA K45 on M16 lower with carbine length buffer tube (lowest ROF buffer/recoil spring combination): 680s.
Best of luck.
MHO, YMMV, etc. Be well.