I have'nt had any leading issues with mine, though I do use the copper plated .22 ammo, don't know if that helps or not.
What you should clean prior to switching back to 5.56 is the chamber, quite a bit of carbon will build up around the "neck" of the chamber insert, which could "possibly" cause a head space issue.
I always clean the whole gun before switching back to 5.56, because the .22 stuff will get it filthy as hell. You'll have it apart anyway, so mind as well clean it.